AP generation

Describe the events that must occur to generate an AP. Relate the sequence of changes in permeability to changes in the ion channels, and explain why the AP is an all-or-none phenomenon.

AP/CNS

Since all APs generated by a given nerve fiber have the same magnitude, how does the CNS “know” whether a stimulus is strong or weak?

EPSP/IPSP

(a) Explain the difference between an EPSP and an IPSP. (b) What specifically determines whether an EPSP or IPSP will be generated at the postsynaptic membrane?

Neuronal activity

Since at any moment a neuron is likely to have thousands of neurons releasing neurotransmitters at its surface, how is neuronal activity (to fire or not to fire) determined?

Neurotransmitter binding

The effects of neurotransmitter binding are very brief. Explain.