VO2 max and functional capacities of physiological systems

In what specific ways would VO2 Max provide important insights about the functional capacities of diverse physiological systems?

Pressure overload on myocardial tissues

In what way might cardiac hypertrophy with pressure overload (e.g. hypertension) affect oxygenation of myocardial tissues?

Effect of exercise on elite runner

If elite runners run at an exercise intensity that does not cause appreciable accumulation of blood lactate, why do some of these athletes appear disoriented and fatigued and forced to slow down toward the end of the race?

Pulmonary ventilation and exercise

How can I justify that pulmonary ventilation does not limit aerobic exercise performance for most healthy people? Followed by a counter argument for the existence of pulmonary ventilation limitations.

Rate pressure product and a patient with angina

Why would a training induced increase in rate pressure product before a person experiences angina during exercise imply enhanced myocardial oxygenation?